The net result was that all three groups had similar live birth rates per embryo transfer (20-23%). However, we did see that those cycles had a higher clinical pregnancy loss rate after a positive pregnancy test (33-42% vs. The paper’s analysis was appropriate and the results showed that of the three type of methods analyzed, the programmed cycles and modified natural cycles had the higher pregnancy rate per embryo transfer compared to the natural cycle (35% vs. These included the programmed cycle that we prefer and is described above, a “natural cycle” where no hormones are given and we rely upon the patient detecting her surge in her urine to time the embryo transfer or a “modified natural cycle” where we induce an ovulation by using an hCG trigger injection to be more sure of the start of progesterone exposure, which is critical to the success of the cycle. looked back at almost 4,500 frozen embryo transfer cycles that were performed using three different treatments. One systematic review article that was published recently as well as a specific large restrospective trial performed in Finland and Denmark titled, “Pregnancy loss after frozen-embryo transfer - a comparison of three protocols.” (Full references below.) In the second article, Tomas et. the number of pregnancies per embryo transferred), we thought it was best to update ourselves. While we are very proud of our implantation rates (i.e. On a pre-determined day, we then transfer the embryo when it and the lining are synchronized to maximize the chances of implantation. Once that goal is reached, we start the patient on progesterone supplementation to create the necessary changes in the endometrium that make it receptive to the embryo. Here at Reproductive partners we usually give our patients estrogen skin patches at the start of a period to prevent ovulation and grow the lining until a certain thickness. This preparation can be done a number of ways, which is reflected in the 5-10 different protocols that are published about this process. One of the topics we had decided as a group earlier in the month to look at was our frozen embryo transfer protocol.Ī frozen embryo transfer involves preparing the endometrium, or the lining of the uterus, until it is ready to accept a previously vitrified embryo. Sometimes this means questioning our own practices to ensure that we continue to have the highest standards. At Reproductive Partners, we are committed to providing the most up to date care. On September 21 st, the physicians at Reproductive Partners, La Jolla sat down at our monthly journal club to discuss two important topics. We are very comfortable with our current regimen. Title: Preventing pregnancy loss after frozen-embryo transfer - a comparison of three protocols.Ĭonclusion: Currently, there is no definitive evidence that there is a superior method of uterine method for frozen embryo transfer. The Typical Infertility Treatment Journey.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |